Hepatotoxicity: Which Medications Cause It? (16,379 Reports Across 776 Drugs)
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Hepatotoxicity has been reported as an adverse event with 776 different drugs in the FDA's FAERS database, with 16,379 total reports. 2,470 of these reports resulted in death.The drugs most commonly associated with Hepatotoxicity are METHOTREXATE, ACETAMINOPHEN, and LEFLUNOMIDE.
16,379
Total Reports
776
Drugs Involved
2,470
Deaths
5,090
Hospitalizations
51.0 yrs
Average Patient Age
59.1% / 40.9%
Female / Male
Which Drugs Cause Hepatotoxicity Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| METHOTREXATE | 1,917 | 0.8% | 130 | 489 | 133 |
| ACETAMINOPHEN | 1,557 | 1.1% | 633 | 898 | 185 |
| LEFLUNOMIDE | 829 | 1.5% | 22 | 174 | 48 |
| HYDROXYCHLOROQUINE | 715 | 1.1% | 34 | 150 | 31 |
| PREDNISONE | 707 | 0.5% | 64 | 275 | 82 |
| RITUXIMAB | 702 | 0.4% | 77 | 211 | 46 |
| ETANERCEPT | 699 | 0.2% | 25 | 133 | 28 |
| ADALIMUMAB | 674 | 0.1% | 27 | 167 | 31 |
| CYCLOPHOSPHAMIDE | 632 | 0.5% | 98 | 155 | 72 |
| SULFASALAZINE | 613 | 1.5% | 26 | 166 | 33 |
| RIBOCICLIB | 585 | 2.1% | 49 | 113 | 65 |
| TOCILIZUMAB | 574 | 0.6% | 26 | 156 | 23 |
| PEMBROLIZUMAB | 542 | 0.7% | 55 | 140 | 21 |
| DEXAMETHASONE | 484 | 0.4% | 85 | 141 | 74 |
| ABATACEPT | 482 | 0.4% | 16 | 124 | 19 |
| VINCRISTINE | 474 | 0.7% | 69 | 132 | 67 |
| DOXORUBICIN | 468 | 0.6% | 58 | 132 | 62 |
| CARBOPLATIN | 452 | 0.5% | 58 | 108 | 21 |
| LETROZOLE | 416 | 1.3% | 29 | 80 | 51 |
| CYTARABINE | 366 | 0.8% | 73 | 91 | 49 |