Does SIROLIMUS Cause Necrosis? 11 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 11 reports of Necrosis have been filed in association with SIROLIMUS (sirolimus). This represents 0.1% of all adverse event reports for SIROLIMUS.
11
Reports of Necrosis with SIROLIMUS
0.1%
of all SIROLIMUS reports
8
Deaths
2
Hospitalizations
How Dangerous Is Necrosis From SIROLIMUS?
Of the 11 reports, 8 (72.7%) resulted in death, 2 (18.2%) required hospitalization, and 1 (9.1%) were considered life-threatening.
Is Necrosis Listed in the Official Label?
Yes, Necrosis is listed as a known adverse reaction in the official FDA drug label for SIROLIMUS.
What Other Side Effects Does SIROLIMUS Cause?
Off label use (1,960)
Drug ineffective (1,005)
Product use in unapproved indication (984)
Transplant rejection (698)
Pneumonia (599)
Product use issue (506)
Alopecia (491)
Acne (482)
Transplant dysfunction (468)
Condition aggravated (433)
What Other Drugs Cause Necrosis?
METHOTREXATE (155)
PREDNISONE (143)
TACROLIMUS (120)
ADALIMUMAB (119)
MYCOPHENOLATE MOFETIL (101)
CYCLOPHOSPHAMIDE (97)
RITUXIMAB (97)
GLATIRAMER (84)
PREDNISOLONE (83)
METHYLPREDNISOLONE (76)
Which SIROLIMUS Alternatives Have Lower Necrosis Risk?
SIROLIMUS vs SIRUKUMAB
SIROLIMUS vs SITAGLIPTIN
SIROLIMUS vs SOAP
SIROLIMUS vs SODIUM
SIROLIMUS vs SODIUM BICARBONATE