Does TOFACITINIB Cause Large intestine perforation? 82 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 82 reports of Large intestine perforation have been filed in association with TOFACITINIB (XELJANZ XR). This represents 0.1% of all adverse event reports for TOFACITINIB.
82
Reports of Large intestine perforation with TOFACITINIB
0.1%
of all TOFACITINIB reports
8
Deaths
61
Hospitalizations
How Dangerous Is Large intestine perforation From TOFACITINIB?
Of the 82 reports, 8 (9.8%) resulted in death, 61 (74.4%) required hospitalization, and 12 (14.6%) were considered life-threatening.
Is Large intestine perforation Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for TOFACITINIB. However, 82 reports have been filed with the FAERS database.
What Other Side Effects Does TOFACITINIB Cause?
Drug ineffective (30,382)
Pain (21,659)
Condition aggravated (16,925)
Arthralgia (15,640)
Fatigue (13,551)
Rheumatoid arthritis (12,277)
Off label use (11,736)
Headache (11,061)
Joint swelling (10,686)
Malaise (9,040)
What Other Drugs Cause Large intestine perforation?
ADALIMUMAB (417)
BEVACIZUMAB (406)
DEXAMETHASONE (243)
PACLITAXEL (191)
CARBOPLATIN (174)
PREDNISOLONE (171)
PREDNISONE (165)
METHYLPREDNISOLONE (164)
FLUOROURACIL (162)
PEMBROLIZUMAB (157)
Which TOFACITINIB Alternatives Have Lower Large intestine perforation Risk?
TOFACITINIB vs TOFERSEN
TOFACITINIB vs TOLNAFTATE
TOFACITINIB vs TOLODODEKIN ALFA
TOFACITINIB vs TOLTERODINE
TOFACITINIB vs TOLVAPTAN