Large intestine perforation: Which Medications Cause It? (4,685 Reports Across 304 Drugs)
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Large intestine perforation has been reported as an adverse event with 304 different drugs in the FDA's FAERS database, with 4,685 total reports. 1,123 of these reports resulted in death.The drugs most commonly associated with Large intestine perforation are ADALIMUMAB, BEVACIZUMAB, and DEXAMETHASONE.
4,685
Total Reports
304
Drugs Involved
1,123
Deaths
3,206
Hospitalizations
60.1 yrs
Average Patient Age
51.5% / 48.5%
Female / Male
Which Drugs Cause Large intestine perforation Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ADALIMUMAB | 417 | 0.1% | 23 | 290 | 12 |
| BEVACIZUMAB | 406 | 0.5% | 148 | 264 | 83 |
| DEXAMETHASONE | 243 | 0.2% | 39 | 145 | 40 |
| PACLITAXEL | 191 | 0.3% | 68 | 114 | 33 |
| CARBOPLATIN | 174 | 0.2% | 49 | 112 | 26 |
| PREDNISOLONE | 171 | 0.2% | 41 | 145 | 44 |
| PREDNISONE | 165 | 0.1% | 42 | 108 | 33 |
| METHYLPREDNISOLONE | 164 | 0.3% | 66 | 106 | 57 |
| FLUOROURACIL | 162 | 0.3% | 54 | 132 | 38 |
| PEMBROLIZUMAB | 157 | 0.2% | 36 | 105 | 25 |
| TOCILIZUMAB | 154 | 0.2% | 31 | 100 | 25 |
| IPILIMUMAB | 129 | 0.4% | 48 | 94 | 32 |
| LENALIDOMIDE | 127 | 0.0% | 26 | 84 | 21 |
| OXALIPLATIN | 127 | 0.2% | 26 | 100 | 40 |
| NIVOLUMAB | 125 | 0.1% | 48 | 97 | 37 |
| TACROLIMUS | 125 | 0.1% | 35 | 87 | 38 |
| CYCLOPHOSPHAMIDE | 122 | 0.1% | 21 | 75 | 17 |
| INFLIXIMAB | 114 | 0.1% | 21 | 87 | 18 |
| METHOTREXATE | 109 | 0.0% | 33 | 85 | 21 |
| LENVATINIB | 106 | 0.3% | 25 | 78 | 19 |