Does TOPIRAMATE Cause Hypertransaminasaemia? 25 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 25 reports of Hypertransaminasaemia have been filed in association with TOPIRAMATE (Topiramate). This represents 0.1% of all adverse event reports for TOPIRAMATE.
25
Reports of Hypertransaminasaemia with TOPIRAMATE
0.1%
of all TOPIRAMATE reports
4
Deaths
17
Hospitalizations
How Dangerous Is Hypertransaminasaemia From TOPIRAMATE?
Of the 25 reports, 4 (16.0%) resulted in death, 17 (68.0%) required hospitalization, and 3 (12.0%) were considered life-threatening.
Is Hypertransaminasaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for TOPIRAMATE. However, 25 reports have been filed with the FAERS database.
What Other Side Effects Does TOPIRAMATE Cause?
Drug ineffective (5,553)
Off label use (4,248)
Product use in unapproved indication (2,173)
Headache (1,997)
Drug intolerance (1,820)
Migraine (1,796)
Nausea (1,691)
Seizure (1,535)
Paraesthesia (1,506)
Dizziness (1,466)
What Other Drugs Cause Hypertransaminasaemia?
METHOTREXATE (436)
ACETAMINOPHEN (326)
PACLITAXEL (318)
CARBOPLATIN (304)
PEMBROLIZUMAB (231)
ATORVASTATIN (207)
CYCLOPHOSPHAMIDE (202)
PREDNISONE (198)
GEMCITABINE (196)
DEXAMETHASONE (169)
Which TOPIRAMATE Alternatives Have Lower Hypertransaminasaemia Risk?
TOPIRAMATE vs TOPOTECAN
TOPIRAMATE vs TOPOTECAN\TOPOTECAN
TOPIRAMATE vs TOPROL
TOPIRAMATE vs TOREMIFENE
TOPIRAMATE vs TORIPALIMAB