Does METHOTREXATE Cause Hypertransaminasaemia? 436 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 436 reports of Hypertransaminasaemia have been filed in association with METHOTREXATE (Methotrexate). This represents 0.2% of all adverse event reports for METHOTREXATE.
436
Reports of Hypertransaminasaemia with METHOTREXATE
0.2%
of all METHOTREXATE reports
53
Deaths
187
Hospitalizations
How Dangerous Is Hypertransaminasaemia From METHOTREXATE?
Of the 436 reports, 53 (12.2%) resulted in death, 187 (42.9%) required hospitalization, and 61 (14.0%) were considered life-threatening.
Is Hypertransaminasaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 436 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Hypertransaminasaemia?
ACETAMINOPHEN (326)
PACLITAXEL (318)
CARBOPLATIN (304)
PEMBROLIZUMAB (231)
ATORVASTATIN (207)
CYCLOPHOSPHAMIDE (202)
PREDNISONE (198)
GEMCITABINE (196)
DEXAMETHASONE (169)
RITUXIMAB (168)
Which METHOTREXATE Alternatives Have Lower Hypertransaminasaemia Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA