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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Cytochrome P450 2D6 Inhibitors [MoA]: Side Effects & Safety Data for 24 Drugs

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Cytochrome P450 2D6 Inhibitors [MoA] includes 24 drugs with a combined 327,240 adverse event reports in the FDA FAERS database. Compare their safety profiles, side effects, and outcomes below.

24
Drugs in Class
327,240
Combined Reports

All Cytochrome P450 2D6 Inhibitors [MoA] Drugs Ranked by Reports

Drug Brand Name Reports Deaths Hosp. Death Rate
SERTRALINE Sertraline Hydrochloride 59,788 6,889 19,327 11.5%
IMATINIB Imatinib 43,161 13,761 7,264 31.9%
EVEROLIMUS EVEROLIMUS 39,640 8,374 11,211 21.1%
ABIRATERONE Abiraterone Acetate 34,511 7,180 8,816 20.8%
AMIODARONE Amiodarone Hydrochloride 25,143 3,845 13,711 15.3%
NILOTINIB nilotinib 23,171 4,543 4,846 19.6%
PAZOPANIB Pazopanib 21,208 5,612 4,347 26.5%
MIRABEGRON MIRABEGRON 20,618 1,338 2,589 6.5%
RITONAVIR Norvir 11,980 1,190 2,925 9.9%
CLOBAZAM Clobazam 10,596 725 3,312 6.8%
RANOLAZINE Ranolazine 9,522 1,048 3,367 11.0%
DESVENLAFAXINE Desvenlafaxine Succinate 8,922 447 1,093 5.0%
DARUNAVIR ETHANOLATE PREZISTA 4,389 397 1,069 9.0%
DARUNAVIR Darunavir 3,558 433 841 12.2%
DRONEDARONE Multaq 2,735 115 611 4.2%
NICARDIPINE NICARDIPINE HYDROCHLORIDE 2,317 182 1,073 7.9%
OSILODROSTAT Isturisa 1,626 191 526 11.7%
ELIGLUSTAT Cerdelga 1,368 18 173 1.3%
ROLAPITANT Varubi 873 252 155 28.9%
VILOXAZINE QELBREE 853 9 59 1.1%
BEROTRALSTAT Orladeyo 548 24 128 4.4%
COBICISTAT Tybost 347 41 109 11.8%
QUINIDINE Quinidine Gluconate 324 42 91 13.0%
TRICLABENDAZOLE EGATEN 42 0 4 N/A

Common Side Effects in Cytochrome P450 2D6 Inhibitors [MoA] Drugs

Side EffectReportsDeaths
Death 30,302 30,187
Drug ineffective 23,684 2,005
Fatigue 16,655 2,009
Nausea 15,105 1,891
Diarrhoea 15,002 1,972
Off label use 11,579 2,040
Dyspnoea 10,832 2,526
Vomiting 10,265 1,974
Dizziness 10,115 1,449
Headache 9,857 1,240
View detailed side effects for this class → Compare drugs in this class →