Cytochrome P450 2D6 Inhibitors [MoA] — Common Side Effects
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| Side Effect | Total Reports | Drugs | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| Death | 30,302 | 22 | 30,187 | 2,016 | 337 |
| Drug ineffective | 23,684 | 23 | 2,005 | 4,923 | 1,824 |
| Fatigue | 16,655 | 22 | 2,009 | 4,134 | 1,046 |
| Nausea | 15,105 | 23 | 1,891 | 4,456 | 966 |
| Diarrhoea | 15,002 | 23 | 1,972 | 4,315 | 869 |
| Off label use | 11,579 | 22 | 2,040 | 4,053 | 1,534 |
| Dyspnoea | 10,832 | 22 | 2,526 | 5,186 | 1,295 |
| Vomiting | 10,265 | 23 | 1,974 | 4,532 | 1,039 |
| Dizziness | 10,115 | 21 | 1,449 | 2,964 | 825 |
| Headache | 9,857 | 22 | 1,240 | 2,413 | 677 |
| Asthenia | 9,083 | 21 | 2,120 | 3,752 | 970 |
| Malaise | 8,921 | 22 | 1,550 | 3,021 | 669 |
| Malignant neoplasm progression | 8,103 | 11 | 2,739 | 1,912 | 290 |
| Drug interaction | 7,598 | 22 | 854 | 3,485 | 743 |
| Rash | 7,396 | 23 | 873 | 1,854 | 699 |
| Decreased appetite | 7,102 | 21 | 1,427 | 2,432 | 515 |
| Pain | 6,993 | 22 | 1,177 | 2,590 | 775 |
| Pyrexia | 6,257 | 22 | 1,482 | 3,558 | 622 |
| Fall | 6,047 | 21 | 1,356 | 3,329 | 431 |
| Toxicity to various agents | 6,034 | 16 | 2,449 | 2,609 | 719 |
| Anxiety | 6,001 | 21 | 356 | 1,616 | 415 |
| Foetal exposure during pregnancy | 5,986 | 13 | 669 | 1,056 | 278 |
| Hypertension | 5,892 | 19 | 923 | 2,328 | 744 |
| Weight decreased | 5,864 | 20 | 600 | 2,114 | 381 |
| Insomnia | 5,827 | 19 | 992 | 1,311 | 535 |
| Product use in unapproved indication | 5,826 | 21 | 1,263 | 1,879 | 818 |
| Pneumonia | 5,589 | 19 | 1,843 | 3,845 | 833 |
| Cough | 5,503 | 19 | 1,172 | 2,021 | 444 |
| Arthralgia | 5,321 | 20 | 1,275 | 1,517 | 531 |
| Condition aggravated | 5,175 | 21 | 1,035 | 2,347 | 988 |