Does ALLOPURINOL Cause Hyperbilirubinaemia? 77 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 77 reports of Hyperbilirubinaemia have been filed in association with ALLOPURINOL (Allopurinol). This represents 0.4% of all adverse event reports for ALLOPURINOL.
77
Reports of Hyperbilirubinaemia with ALLOPURINOL
0.4%
of all ALLOPURINOL reports
11
Deaths
64
Hospitalizations
How Dangerous Is Hyperbilirubinaemia From ALLOPURINOL?
Of the 77 reports, 11 (14.3%) resulted in death, 64 (83.1%) required hospitalization, and 27 (35.1%) were considered life-threatening.
Is Hyperbilirubinaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for ALLOPURINOL. However, 77 reports have been filed with the FAERS database.
What Other Side Effects Does ALLOPURINOL Cause?
Drug reaction with eosinophilia and systemic symptoms (2,943)
Acute kidney injury (1,583)
Rash (1,103)
Off label use (921)
Pyrexia (913)
Dyspnoea (905)
Toxic epidermal necrolysis (858)
Pruritus (836)
Diarrhoea (819)
Drug ineffective (780)
What Other Drugs Cause Hyperbilirubinaemia?
METHOTREXATE (603)
RIBAVIRIN (560)
VINCRISTINE (479)
CYTARABINE (397)
PEGASPARGASE (349)
ACETAMINOPHEN (330)
CYCLOPHOSPHAMIDE (330)
DEXAMETHASONE (315)
CAPECITABINE (279)
SOFOSBUVIR (260)
Which ALLOPURINOL Alternatives Have Lower Hyperbilirubinaemia Risk?
ALLOPURINOL vs ALMOTRIPTAN
ALLOPURINOL vs ALMOTRIPTAN MALATE
ALLOPURINOL vs ALOE VERA LEAF
ALLOPURINOL vs ALOGLIPTIN
ALLOPURINOL vs ALOGLIPTIN\METFORMIN