Does METHOTREXATE Cause Hyperbilirubinaemia? 603 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 603 reports of Hyperbilirubinaemia have been filed in association with METHOTREXATE (Methotrexate). This represents 0.2% of all adverse event reports for METHOTREXATE.
603
Reports of Hyperbilirubinaemia with METHOTREXATE
0.2%
of all METHOTREXATE reports
75
Deaths
293
Hospitalizations
How Dangerous Is Hyperbilirubinaemia From METHOTREXATE?
Of the 603 reports, 75 (12.4%) resulted in death, 293 (48.6%) required hospitalization, and 43 (7.1%) were considered life-threatening.
Is Hyperbilirubinaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 603 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Hyperbilirubinaemia?
RIBAVIRIN (560)
VINCRISTINE (479)
CYTARABINE (397)
PEGASPARGASE (349)
ACETAMINOPHEN (330)
CYCLOPHOSPHAMIDE (330)
DEXAMETHASONE (315)
CAPECITABINE (279)
SOFOSBUVIR (260)
PREDNISONE (259)
Which METHOTREXATE Alternatives Have Lower Hyperbilirubinaemia Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA