Does PEGASPARGASE Cause Hyperbilirubinaemia? 349 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 349 reports of Hyperbilirubinaemia have been filed in association with PEGASPARGASE (ONCASPAR). This represents 3.0% of all adverse event reports for PEGASPARGASE.
349
Reports of Hyperbilirubinaemia with PEGASPARGASE
3.0%
of all PEGASPARGASE reports
33
Deaths
145
Hospitalizations
How Dangerous Is Hyperbilirubinaemia From PEGASPARGASE?
Of the 349 reports, 33 (9.5%) resulted in death, 145 (41.5%) required hospitalization, and 19 (5.4%) were considered life-threatening.
Is Hyperbilirubinaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PEGASPARGASE. However, 349 reports have been filed with the FAERS database.
What Other Side Effects Does PEGASPARGASE Cause?
Febrile neutropenia (1,589)
Pyrexia (706)
Febrile bone marrow aplasia (668)
Sepsis (548)
Vomiting (530)
Neutropenia (521)
Abdominal pain (469)
Hypertriglyceridaemia (399)
Hypotension (388)
Thrombocytopenia (382)
What Other Drugs Cause Hyperbilirubinaemia?
METHOTREXATE (603)
RIBAVIRIN (560)
VINCRISTINE (479)
CYTARABINE (397)
ACETAMINOPHEN (330)
CYCLOPHOSPHAMIDE (330)
DEXAMETHASONE (315)
CAPECITABINE (279)
SOFOSBUVIR (260)
PREDNISONE (259)
Which PEGASPARGASE Alternatives Have Lower Hyperbilirubinaemia Risk?
PEGASPARGASE vs PEGASYS
PEGASPARGASE vs PEGCETACOPLAN
PEGASPARGASE vs PEGFILGRASTIM
PEGASPARGASE vs PEGFILGRASTIM-APGF
PEGASPARGASE vs PEGFILGRASTIM-BMEZ