Does APREMILAST Cause Duodenal ulcer perforation? 1,672 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 1,672 reports of Duodenal ulcer perforation have been filed in association with APREMILAST (Otezla). This represents 1.2% of all adverse event reports for APREMILAST.
1,672
Reports of Duodenal ulcer perforation with APREMILAST
1.2%
of all APREMILAST reports
1,452
Deaths
1,286
Hospitalizations
How Dangerous Is Duodenal ulcer perforation From APREMILAST?
Of the 1,672 reports, 1,452 (86.8%) resulted in death, 1,286 (76.9%) required hospitalization, and 1,334 (79.8%) were considered life-threatening.
Is Duodenal ulcer perforation Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for APREMILAST. However, 1,672 reports have been filed with the FAERS database.
What Other Side Effects Does APREMILAST Cause?
Diarrhoea (23,752)
Nausea (21,352)
Psoriasis (19,255)
Headache (17,024)
Drug ineffective (14,121)
Abdominal discomfort (7,653)
Psoriatic arthropathy (7,035)
Vomiting (5,959)
Rash (5,883)
Pain (5,676)
What Other Drugs Cause Duodenal ulcer perforation?
METHOTREXATE (4,239)
LEFLUNOMIDE (4,200)
FOLIC ACID (4,152)
ABATACEPT (4,147)
TOCILIZUMAB (4,130)
DICLOFENAC (4,120)
CETIRIZINE (4,117)
DESOXIMETASONE (4,084)
RITUXIMAB (4,081)
PREDNISONE (4,060)
Which APREMILAST Alternatives Have Lower Duodenal ulcer perforation Risk?
APREMILAST vs APREPITANT
APREMILAST vs APROTININ
APREMILAST vs ARANESP
APREMILAST vs ARAVA
APREMILAST vs AREDIA