Does METHOTREXATE Cause Duodenal ulcer perforation? 4,239 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 4,239 reports of Duodenal ulcer perforation have been filed in association with METHOTREXATE (Methotrexate). This represents 1.7% of all adverse event reports for METHOTREXATE.
4,239
Reports of Duodenal ulcer perforation with METHOTREXATE
1.7%
of all METHOTREXATE reports
1,852
Deaths
2,275
Hospitalizations
How Dangerous Is Duodenal ulcer perforation From METHOTREXATE?
Of the 4,239 reports, 1,852 (43.7%) resulted in death, 2,275 (53.7%) required hospitalization, and 2,163 (51.0%) were considered life-threatening.
Is Duodenal ulcer perforation Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 4,239 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Duodenal ulcer perforation?
LEFLUNOMIDE (4,200)
FOLIC ACID (4,152)
ABATACEPT (4,147)
TOCILIZUMAB (4,130)
DICLOFENAC (4,120)
CETIRIZINE (4,117)
DESOXIMETASONE (4,084)
RITUXIMAB (4,081)
PREDNISONE (4,060)
ALENDRONATE (4,035)
Which METHOTREXATE Alternatives Have Lower Duodenal ulcer perforation Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA