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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Duodenal ulcer perforation: Which Medications Cause It? (5,944 Reports Across 387 Drugs)

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Duodenal ulcer perforation has been reported as an adverse event with 387 different drugs in the FDA's FAERS database, with 5,944 total reports. 2,480 of these reports resulted in death.The drugs most commonly associated with Duodenal ulcer perforation are METHOTREXATE, LEFLUNOMIDE, and FOLIC ACID.

5,944
Total Reports
387
Drugs Involved
2,480
Deaths
3,517
Hospitalizations
47.4 yrs
Average Patient Age
92.6% / 7.4%
Female / Male

Which Drugs Cause Duodenal ulcer perforation Most Often?

Drug Reports % of Drug Reports Deaths Hosp. Life-Threat.
METHOTREXATE 4,239 1.7% 1,852 2,275 2,163
LEFLUNOMIDE 4,200 7.4% 1,824 2,314 2,196
FOLIC ACID 4,152 18.2% 1,820 2,201 2,073
ABATACEPT 4,147 3.6% 1,603 2,115 2,025
TOCILIZUMAB 4,130 4.2% 1,858 2,207 1,991
DICLOFENAC 4,120 4.8% 1,909 2,241 2,098
CETIRIZINE 4,117 8.6% 1,826 2,174 2,069
DESOXIMETASONE 4,084 35.1% 1,808 2,141 2,052
RITUXIMAB 4,081 2.3% 1,794 2,286 2,053
PREDNISONE 4,060 2.6% 1,735 2,184 2,052
ALENDRONATE 4,035 14.5% 1,797 2,148 2,058
HYDROXYCHLOROQUINE 4,007 6.0% 1,710 2,088 1,966
ADALIMUMAB 3,983 0.8% 1,724 2,080 1,980
INFLIXIMAB 3,896 2.8% 1,648 2,001 1,911
CERTOLIZUMAB PEGOL 3,893 3.9% 1,687 1,996 1,911
SULFASALAZINE 3,866 9.6% 1,650 2,010 1,911
GOLIMUMAB 3,770 5.5% 1,580 1,922 1,833
PSEUDOEPHEDRINE 3,661 28.0% 1,580 1,962 1,868
TOFACITINIB 3,606 2.3% 1,480 1,834 1,742
ETANERCEPT 3,501 1.0% 1,386 1,753 1,621

View all 387 drugs →

Top 3 Drugs Associated With Duodenal ulcer perforation

4,239 reports
4,200 reports
4,152 reports

Related Side Effects

Drug ineffective (1,049,718) Off label use (762,782) Death (660,423) Fatigue (599,248) Nausea (562,301) Diarrhoea (491,550) Pain (471,975) Headache (460,069) Dyspnoea (409,496) Dizziness (352,922)