Does BUPIVACAINE Cause Cardiotoxicity? 74 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 74 reports of Cardiotoxicity have been filed in association with BUPIVACAINE (Bupivacaine Hydrochloride). This represents 0.7% of all adverse event reports for BUPIVACAINE.
74
Reports of Cardiotoxicity with BUPIVACAINE
0.7%
of all BUPIVACAINE reports
25
Deaths
32
Hospitalizations
How Dangerous Is Cardiotoxicity From BUPIVACAINE?
Of the 74 reports, 25 (33.8%) resulted in death, 32 (43.2%) required hospitalization, and 28 (37.8%) were considered life-threatening.
Is Cardiotoxicity Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for BUPIVACAINE. However, 74 reports have been filed with the FAERS database.
What Other Side Effects Does BUPIVACAINE Cause?
Drug ineffective (3,068)
Off label use (912)
Pain (746)
Anaesthetic complication (585)
Maternal exposure during pregnancy (491)
Hypotension (460)
Hypoaesthesia (455)
Exposure during pregnancy (391)
Nausea (328)
Drug withdrawal syndrome (280)
What Other Drugs Cause Cardiotoxicity?
DOXORUBICIN (1,366)
CYCLOPHOSPHAMIDE (1,009)
TRASTUZUMAB (950)
VINCRISTINE (446)
FLUOROURACIL (425)
RITUXIMAB (389)
ETOPOSIDE (366)
CAPECITABINE (307)
TOCILIZUMAB (278)
PREDNISONE (277)
Which BUPIVACAINE Alternatives Have Lower Cardiotoxicity Risk?
BUPIVACAINE vs BUPIVACAINE\BUPIVACAINE ANHYDROUS
BUPIVACAINE vs BUPIVACAINE\EPINEPHRINE
BUPIVACAINE vs BUPIVACAINE\MELOXICAM
BUPIVACAINE vs BUPRENORPHINE
BUPIVACAINE vs BUPRENORPHINE\NALOXONE