Cardiotoxicity: Which Medications Cause It? (6,973 Reports Across 363 Drugs)
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Cardiotoxicity has been reported as an adverse event with 363 different drugs in the FDA's FAERS database, with 6,973 total reports. 1,082 of these reports resulted in death.The drugs most commonly associated with Cardiotoxicity are DOXORUBICIN, CYCLOPHOSPHAMIDE, and TRASTUZUMAB.
6,973
Total Reports
363
Drugs Involved
1,082
Deaths
2,518
Hospitalizations
48.4 yrs
Average Patient Age
60.3% / 39.7%
Female / Male
Which Drugs Cause Cardiotoxicity Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| DOXORUBICIN | 1,366 | 1.7% | 290 | 266 | 118 |
| CYCLOPHOSPHAMIDE | 1,009 | 0.8% | 231 | 199 | 59 |
| TRASTUZUMAB | 950 | 2.0% | 61 | 101 | 29 |
| VINCRISTINE | 446 | 0.6% | 112 | 94 | 27 |
| FLUOROURACIL | 425 | 0.8% | 63 | 152 | 59 |
| RITUXIMAB | 389 | 0.2% | 111 | 70 | 26 |
| ETOPOSIDE | 366 | 0.7% | 83 | 87 | 23 |
| CAPECITABINE | 307 | 0.5% | 39 | 129 | 25 |
| TOCILIZUMAB | 278 | 0.3% | 44 | 100 | 12 |
| PREDNISONE | 277 | 0.2% | 68 | 49 | 13 |
| PACLITAXEL | 269 | 0.4% | 39 | 42 | 19 |
| DOCETAXEL | 262 | 0.4% | 43 | 32 | 7 |
| PERTUZUMAB | 260 | 1.2% | 10 | 33 | 12 |
| OXALIPLATIN | 259 | 0.5% | 19 | 122 | 45 |
| METHOTREXATE | 254 | 0.1% | 80 | 66 | 21 |
| CARBOPLATIN | 251 | 0.3% | 40 | 70 | 14 |
| CYTARABINE | 242 | 0.6% | 72 | 54 | 25 |
| DEXAMETHASONE | 217 | 0.2% | 53 | 58 | 28 |
| EPIRUBICIN | 215 | 1.3% | 45 | 42 | 3 |
| AMLODIPINE | 182 | 0.3% | 30 | 136 | 78 |