Does FLUOROURACIL Cause Cardiotoxicity? 425 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 425 reports of Cardiotoxicity have been filed in association with FLUOROURACIL (FLUOROURACIL). This represents 0.8% of all adverse event reports for FLUOROURACIL.
425
Reports of Cardiotoxicity with FLUOROURACIL
0.8%
of all FLUOROURACIL reports
63
Deaths
152
Hospitalizations
How Dangerous Is Cardiotoxicity From FLUOROURACIL?
Of the 425 reports, 63 (14.8%) resulted in death, 152 (35.8%) required hospitalization, and 59 (13.9%) were considered life-threatening.
Is Cardiotoxicity Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for FLUOROURACIL. However, 425 reports have been filed with the FAERS database.
What Other Side Effects Does FLUOROURACIL Cause?
Diarrhoea (5,373)
Neutropenia (4,400)
Nausea (3,757)
Vomiting (2,836)
Off label use (2,788)
Neuropathy peripheral (2,605)
Thrombocytopenia (2,426)
Fatigue (2,421)
Disease progression (2,377)
Febrile neutropenia (2,230)
What Other Drugs Cause Cardiotoxicity?
DOXORUBICIN (1,366)
CYCLOPHOSPHAMIDE (1,009)
TRASTUZUMAB (950)
VINCRISTINE (446)
RITUXIMAB (389)
ETOPOSIDE (366)
CAPECITABINE (307)
TOCILIZUMAB (278)
PREDNISONE (277)
PACLITAXEL (269)
Which FLUOROURACIL Alternatives Have Lower Cardiotoxicity Risk?
FLUOROURACIL vs FLUOROURACIL\IRINOTECAN\LEUCOVORIN
FLUOROURACIL vs FLUOROURACIL\IRINOTECAN\LEUCOVORIN\OXALIPLATIN
FLUOROURACIL vs FLUOROURACIL\LEUCOVORIN\OXALIPLATIN
FLUOROURACIL vs FLUOXETINE
FLUOROURACIL vs FLUOXETINE\FLUOXETINE