Does CODEINE Cause Duodenal ulcer perforation? 227 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 227 reports of Duodenal ulcer perforation have been filed in association with CODEINE (Codeine-Guaifenesin). This represents 1.0% of all adverse event reports for CODEINE.
227
Reports of Duodenal ulcer perforation with CODEINE
1.0%
of all CODEINE reports
216
Deaths
187
Hospitalizations
How Dangerous Is Duodenal ulcer perforation From CODEINE?
Of the 227 reports, 216 (95.2%) resulted in death, 187 (82.4%) required hospitalization, and 189 (83.3%) were considered life-threatening.
Is Duodenal ulcer perforation Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for CODEINE. However, 227 reports have been filed with the FAERS database.
What Other Side Effects Does CODEINE Cause?
Drug hypersensitivity (7,479)
Toxicity to various agents (2,951)
Drug ineffective (2,632)
Drug abuse (2,122)
Pain (2,024)
Rash (1,931)
Nausea (1,907)
Rheumatoid arthritis (1,861)
Headache (1,701)
Off label use (1,662)
What Other Drugs Cause Duodenal ulcer perforation?
METHOTREXATE (4,239)
LEFLUNOMIDE (4,200)
FOLIC ACID (4,152)
ABATACEPT (4,147)
TOCILIZUMAB (4,130)
DICLOFENAC (4,120)
CETIRIZINE (4,117)
DESOXIMETASONE (4,084)
RITUXIMAB (4,081)
PREDNISONE (4,060)
Which CODEINE Alternatives Have Lower Duodenal ulcer perforation Risk?
CODEINE vs CODEINE\GUAIFENESIN
CODEINE vs CODEINE\IBUPROFEN
CODEINE vs CODEINE\PROMETHAZINE
CODEINE vs COLCHICINE
CODEINE vs COLCHICINE\DICYCLOMINE