Does DURVALUMAB Cause Agranulocytosis? 33 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 33 reports of Agranulocytosis have been filed in association with DURVALUMAB (IMFINZI). This represents 0.2% of all adverse event reports for DURVALUMAB.
33
Reports of Agranulocytosis with DURVALUMAB
0.2%
of all DURVALUMAB reports
16
Deaths
8
Hospitalizations
How Dangerous Is Agranulocytosis From DURVALUMAB?
Of the 33 reports, 16 (48.5%) resulted in death, 8 (24.2%) required hospitalization, and 2 (6.1%) were considered life-threatening.
Is Agranulocytosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for DURVALUMAB. However, 33 reports have been filed with the FAERS database.
What Other Side Effects Does DURVALUMAB Cause?
Death (2,817)
Malignant neoplasm progression (1,330)
Pneumonitis (827)
Radiation pneumonitis (786)
Pyrexia (573)
Diarrhoea (530)
Pneumonia (453)
Dyspnoea (444)
Interstitial lung disease (430)
Off label use (395)
What Other Drugs Cause Agranulocytosis?
CLOZAPINE (1,766)
CYCLOPHOSPHAMIDE (1,242)
RITUXIMAB (1,154)
SULFAMETHOXAZOLE\TRIMETHOPRIM (797)
PANTOPRAZOLE (599)
METHOTREXATE (550)
SODIUM (549)
EPIRUBICIN (491)
METAMIZOLE (438)
DOCETAXEL (436)
Which DURVALUMAB Alternatives Have Lower Agranulocytosis Risk?
DURVALUMAB vs DUTASTERIDE
DURVALUMAB vs DUTASTERIDE\TAMSULOSIN
DURVALUMAB vs DUVELISIB
DURVALUMAB vs DYDROGESTERONE
DURVALUMAB vs EBASTINE