Does METHOTREXATE Cause Agranulocytosis? 550 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 550 reports of Agranulocytosis have been filed in association with METHOTREXATE (Methotrexate). This represents 0.2% of all adverse event reports for METHOTREXATE.
550
Reports of Agranulocytosis with METHOTREXATE
0.2%
of all METHOTREXATE reports
115
Deaths
385
Hospitalizations
How Dangerous Is Agranulocytosis From METHOTREXATE?
Of the 550 reports, 115 (20.9%) resulted in death, 385 (70.0%) required hospitalization, and 148 (26.9%) were considered life-threatening.
Is Agranulocytosis Listed in the Official Label?
Yes, Agranulocytosis is listed as a known adverse reaction in the official FDA drug label for METHOTREXATE.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Agranulocytosis?
CLOZAPINE (1,766)
CYCLOPHOSPHAMIDE (1,242)
RITUXIMAB (1,154)
SULFAMETHOXAZOLE\TRIMETHOPRIM (797)
PANTOPRAZOLE (599)
SODIUM (549)
EPIRUBICIN (491)
METAMIZOLE (438)
DOCETAXEL (436)
CARBOPLATIN (407)
Which METHOTREXATE Alternatives Have Lower Agranulocytosis Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA