Agranulocytosis: Which Medications Cause It? (12,963 Reports Across 648 Drugs)
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Agranulocytosis has been reported as an adverse event with 648 different drugs in the FDA's FAERS database, with 12,963 total reports. 1,198 of these reports resulted in death.The drugs most commonly associated with Agranulocytosis are CLOZAPINE, CYCLOPHOSPHAMIDE, and RITUXIMAB.
12,963
Total Reports
648
Drugs Involved
1,198
Deaths
7,626
Hospitalizations
55.0 yrs
Average Patient Age
52.9% / 47.1%
Female / Male
Which Drugs Cause Agranulocytosis Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CLOZAPINE | 1,766 | 1.9% | 111 | 552 | 505 |
| CYCLOPHOSPHAMIDE | 1,242 | 1.0% | 63 | 438 | 182 |
| RITUXIMAB | 1,154 | 0.7% | 48 | 742 | 183 |
| SULFAMETHOXAZOLE\TRIMETHOPRIM | 797 | 2.1% | 40 | 625 | 152 |
| PANTOPRAZOLE | 599 | 0.8% | 61 | 440 | 164 |
| METHOTREXATE | 550 | 0.2% | 115 | 385 | 148 |
| SODIUM | 549 | 2.4% | 1 | 40 | 8 |
| EPIRUBICIN | 491 | 3.0% | 12 | 67 | 22 |
| METAMIZOLE | 438 | 7.8% | 75 | 341 | 167 |
| DOCETAXEL | 436 | 0.7% | 28 | 185 | 86 |
| CARBOPLATIN | 407 | 0.5% | 71 | 289 | 132 |
| DOXORUBICIN | 406 | 0.5% | 45 | 251 | 146 |
| VALACYCLOVIR | 381 | 2.9% | 5 | 323 | 79 |
| VINCRISTINE | 344 | 0.5% | 42 | 205 | 118 |
| LANSOPRAZOLE | 336 | 0.6% | 43 | 268 | 53 |
| ACETAMINOPHEN | 335 | 0.2% | 25 | 260 | 106 |
| FUROSEMIDE | 322 | 0.6% | 59 | 223 | 78 |
| IBUPROFEN | 303 | 0.4% | 23 | 246 | 106 |
| ETOPOSIDE | 299 | 0.6% | 58 | 176 | 88 |
| CYTARABINE | 297 | 0.7% | 24 | 169 | 53 |