Does FLUOROURACIL Cause Cholangitis? 175 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 175 reports of Cholangitis have been filed in association with FLUOROURACIL (FLUOROURACIL). This represents 0.3% of all adverse event reports for FLUOROURACIL.
175
Reports of Cholangitis with FLUOROURACIL
0.3%
of all FLUOROURACIL reports
37
Deaths
125
Hospitalizations
How Dangerous Is Cholangitis From FLUOROURACIL?
Of the 175 reports, 37 (21.1%) resulted in death, 125 (71.4%) required hospitalization, and 6 (3.4%) were considered life-threatening.
Is Cholangitis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for FLUOROURACIL. However, 175 reports have been filed with the FAERS database.
What Other Side Effects Does FLUOROURACIL Cause?
Diarrhoea (5,373)
Neutropenia (4,400)
Nausea (3,757)
Vomiting (2,836)
Off label use (2,788)
Neuropathy peripheral (2,605)
Thrombocytopenia (2,426)
Fatigue (2,421)
Disease progression (2,377)
Febrile neutropenia (2,230)
What Other Drugs Cause Cholangitis?
NIVOLUMAB (389)
PEMBROLIZUMAB (357)
PACLITAXEL (289)
GEMCITABINE (225)
TACROLIMUS (213)
BEVACIZUMAB (176)
DURVALUMAB (157)
OXALIPLATIN (147)
IRINOTECAN (146)
ATEZOLIZUMAB (145)
Which FLUOROURACIL Alternatives Have Lower Cholangitis Risk?
FLUOROURACIL vs FLUOROURACIL\IRINOTECAN\LEUCOVORIN
FLUOROURACIL vs FLUOROURACIL\IRINOTECAN\LEUCOVORIN\OXALIPLATIN
FLUOROURACIL vs FLUOROURACIL\LEUCOVORIN\OXALIPLATIN
FLUOROURACIL vs FLUOXETINE
FLUOROURACIL vs FLUOXETINE\FLUOXETINE