Does IRINOTECAN Cause Cholangitis? 146 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 146 reports of Cholangitis have been filed in association with IRINOTECAN (Irinotecan Hydrochloride). This represents 0.5% of all adverse event reports for IRINOTECAN.
146
Reports of Cholangitis with IRINOTECAN
0.5%
of all IRINOTECAN reports
31
Deaths
98
Hospitalizations
How Dangerous Is Cholangitis From IRINOTECAN?
Of the 146 reports, 31 (21.2%) resulted in death, 98 (67.1%) required hospitalization, and 6 (4.1%) were considered life-threatening.
Is Cholangitis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for IRINOTECAN. However, 146 reports have been filed with the FAERS database.
What Other Side Effects Does IRINOTECAN Cause?
Diarrhoea (4,157)
Neutropenia (2,533)
Nausea (2,374)
Disease progression (2,018)
Off label use (2,018)
Vomiting (1,944)
Fatigue (1,515)
Febrile neutropenia (1,357)
Anaemia (1,231)
Thrombocytopenia (1,214)
What Other Drugs Cause Cholangitis?
NIVOLUMAB (389)
PEMBROLIZUMAB (357)
PACLITAXEL (289)
GEMCITABINE (225)
TACROLIMUS (213)
BEVACIZUMAB (176)
FLUOROURACIL (175)
DURVALUMAB (157)
OXALIPLATIN (147)
ATEZOLIZUMAB (145)
Which IRINOTECAN Alternatives Have Lower Cholangitis Risk?
IRINOTECAN vs IRON
IRINOTECAN vs IRON DEXTRAN
IRINOTECAN vs IRON ISOMALTOSIDE 1000
IRINOTECAN vs IRON POLYMALTOSE
IRINOTECAN vs IRON SUCROSE