Does HYDROCHLOROTHIAZIDE Cause Agranulocytosis? 59 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 59 reports of Agranulocytosis have been filed in association with HYDROCHLOROTHIAZIDE (Irbesartan and Hydrochlorothiazide). This represents 0.3% of all adverse event reports for HYDROCHLOROTHIAZIDE.
59
Reports of Agranulocytosis with HYDROCHLOROTHIAZIDE
0.3%
of all HYDROCHLOROTHIAZIDE reports
1
Deaths
57
Hospitalizations
How Dangerous Is Agranulocytosis From HYDROCHLOROTHIAZIDE?
Of the 59 reports, 1 (1.7%) resulted in death, 57 (96.6%) required hospitalization, and 14 (23.7%) were considered life-threatening.
Is Agranulocytosis Listed in the Official Label?
Yes, Agranulocytosis is listed as a known adverse reaction in the official FDA drug label for HYDROCHLOROTHIAZIDE.
What Other Side Effects Does HYDROCHLOROTHIAZIDE Cause?
Hyponatraemia (2,138)
Drug ineffective (1,889)
Acute kidney injury (1,838)
Nausea (1,536)
Dyspnoea (1,521)
Dizziness (1,469)
Headache (1,419)
Hypotension (1,347)
Fall (1,323)
Malaise (1,312)
What Other Drugs Cause Agranulocytosis?
CLOZAPINE (1,766)
CYCLOPHOSPHAMIDE (1,242)
RITUXIMAB (1,154)
SULFAMETHOXAZOLE\TRIMETHOPRIM (797)
PANTOPRAZOLE (599)
METHOTREXATE (550)
SODIUM (549)
EPIRUBICIN (491)
METAMIZOLE (438)
DOCETAXEL (436)
Which HYDROCHLOROTHIAZIDE Alternatives Have Lower Agranulocytosis Risk?
HYDROCHLOROTHIAZIDE vs HYDROCHLOROTHIAZIDE\IRBESARTAN
HYDROCHLOROTHIAZIDE vs HYDROCHLOROTHIAZIDE\LISINOPRIL
HYDROCHLOROTHIAZIDE vs HYDROCHLOROTHIAZIDE\LOSARTAN
HYDROCHLOROTHIAZIDE vs HYDROCHLOROTHIAZIDE\METOPROLOL
HYDROCHLOROTHIAZIDE vs HYDROCHLOROTHIAZIDE\NEBIVOLOL