Does IRINOTECAN Cause Large intestine perforation? 84 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 84 reports of Large intestine perforation have been filed in association with IRINOTECAN (Irinotecan Hydrochloride). This represents 0.3% of all adverse event reports for IRINOTECAN.
84
Reports of Large intestine perforation with IRINOTECAN
0.3%
of all IRINOTECAN reports
27
Deaths
54
Hospitalizations
How Dangerous Is Large intestine perforation From IRINOTECAN?
Of the 84 reports, 27 (32.1%) resulted in death, 54 (64.3%) required hospitalization, and 16 (19.0%) were considered life-threatening.
Is Large intestine perforation Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for IRINOTECAN. However, 84 reports have been filed with the FAERS database.
What Other Side Effects Does IRINOTECAN Cause?
Diarrhoea (4,157)
Neutropenia (2,533)
Nausea (2,374)
Disease progression (2,018)
Off label use (2,018)
Vomiting (1,944)
Fatigue (1,515)
Febrile neutropenia (1,357)
Anaemia (1,231)
Thrombocytopenia (1,214)
What Other Drugs Cause Large intestine perforation?
ADALIMUMAB (417)
BEVACIZUMAB (406)
DEXAMETHASONE (243)
PACLITAXEL (191)
CARBOPLATIN (174)
PREDNISOLONE (171)
PREDNISONE (165)
METHYLPREDNISOLONE (164)
FLUOROURACIL (162)
PEMBROLIZUMAB (157)
Which IRINOTECAN Alternatives Have Lower Large intestine perforation Risk?
IRINOTECAN vs IRON
IRINOTECAN vs IRON DEXTRAN
IRINOTECAN vs IRON ISOMALTOSIDE 1000
IRINOTECAN vs IRON POLYMALTOSE
IRINOTECAN vs IRON SUCROSE