Does ISONIAZID Cause Hyperbilirubinaemia? 30 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 30 reports of Hyperbilirubinaemia have been filed in association with ISONIAZID (Isoniazid). This represents 0.4% of all adverse event reports for ISONIAZID.
30
Reports of Hyperbilirubinaemia with ISONIAZID
0.4%
of all ISONIAZID reports
6
Deaths
17
Hospitalizations
How Dangerous Is Hyperbilirubinaemia From ISONIAZID?
Of the 30 reports, 6 (20.0%) resulted in death, 17 (56.7%) required hospitalization, and 6 (20.0%) were considered life-threatening.
Is Hyperbilirubinaemia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for ISONIAZID. However, 30 reports have been filed with the FAERS database.
What Other Side Effects Does ISONIAZID Cause?
Drug-induced liver injury (766)
Drug ineffective (607)
Drug reaction with eosinophilia and systemic symptoms (550)
Pyrexia (517)
Nausea (488)
Paradoxical drug reaction (433)
Off label use (406)
Drug resistance (367)
Hepatotoxicity (349)
Headache (324)
What Other Drugs Cause Hyperbilirubinaemia?
METHOTREXATE (603)
RIBAVIRIN (560)
VINCRISTINE (479)
CYTARABINE (397)
PEGASPARGASE (349)
ACETAMINOPHEN (330)
CYCLOPHOSPHAMIDE (330)
DEXAMETHASONE (315)
CAPECITABINE (279)
SOFOSBUVIR (260)
Which ISONIAZID Alternatives Have Lower Hyperbilirubinaemia Risk?
ISONIAZID vs ISONIAZID\PYRAZINAMIDE\RIFAMPIN
ISONIAZID vs ISONIAZID\PYRIDOXINE\SULFAMETHOXAZOLE\TRIMETHOPRIM
ISONIAZID vs ISONIAZID\RIFAMPIN
ISONIAZID vs ISOPROPANOLAMINE
ISONIAZID vs ISOPROPYL ALCOHOL