Does MANNITOL Cause Necrosis? 5 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 5 reports of Necrosis have been filed in association with MANNITOL (Osmitrol). This represents 0.3% of all adverse event reports for MANNITOL.
5
Reports of Necrosis with MANNITOL
0.3%
of all MANNITOL reports
4
Deaths
3
Hospitalizations
How Dangerous Is Necrosis From MANNITOL?
Of the 5 reports, 4 (80.0%) resulted in death, 3 (60.0%) required hospitalization, and 1 (20.0%) were considered life-threatening.
Is Necrosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for MANNITOL. However, 5 reports have been filed with the FAERS database.
What Other Side Effects Does MANNITOL Cause?
Drug ineffective (276)
Condition aggravated (205)
Nausea (167)
Off label use (159)
Hyponatraemia (153)
Vomiting (147)
Renal impairment (144)
Pruritus (140)
Sepsis (136)
Multiple organ dysfunction syndrome (131)
What Other Drugs Cause Necrosis?
METHOTREXATE (155)
PREDNISONE (143)
TACROLIMUS (120)
ADALIMUMAB (119)
MYCOPHENOLATE MOFETIL (101)
CYCLOPHOSPHAMIDE (97)
RITUXIMAB (97)
GLATIRAMER (84)
PREDNISOLONE (83)
METHYLPREDNISOLONE (76)
Which MANNITOL Alternatives Have Lower Necrosis Risk?
MANNITOL vs MAPROTILINE
MANNITOL vs MARALIXIBAT
MANNITOL vs MARAVIROC
MANNITOL vs MARIBAVIR
MANNITOL vs MAVACAMTEN