Does MELPHALAN Cause Aplasia? 78 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 78 reports of Aplasia have been filed in association with MELPHALAN (Melphalan Hydrochloride). This represents 0.5% of all adverse event reports for MELPHALAN.
78
Reports of Aplasia with MELPHALAN
0.5%
of all MELPHALAN reports
13
Deaths
49
Hospitalizations
How Dangerous Is Aplasia From MELPHALAN?
Of the 78 reports, 13 (16.7%) resulted in death, 49 (62.8%) required hospitalization, and 18 (23.1%) were considered life-threatening.
Is Aplasia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for MELPHALAN. However, 78 reports have been filed with the FAERS database.
What Other Side Effects Does MELPHALAN Cause?
Off label use (2,002)
Febrile neutropenia (931)
Drug ineffective (853)
Neutropenia (810)
Mucosal inflammation (804)
Plasma cell myeloma (781)
Product use in unapproved indication (765)
Thrombocytopenia (701)
Diarrhoea (698)
Pyrexia (667)
What Other Drugs Cause Aplasia?
CYTARABINE (229)
ETOPOSIDE (217)
CYCLOPHOSPHAMIDE (213)
METHOTREXATE (199)
VINCRISTINE (167)
DOXORUBICIN (144)
CARBOPLATIN (136)
DEXAMETHASONE (129)
RITUXIMAB (98)
IFOSFAMIDE (88)
Which MELPHALAN Alternatives Have Lower Aplasia Risk?
MELPHALAN vs MEMANTINE
MELPHALAN vs MENINGOCOCCAL GROUP B VACCINE
MELPHALAN vs MENINGOCOCCAL POLYSACCHARIDE VACCINE A\NEISSERIA MENINGITIDIS GROUP A CAPSULAR POLYSACCHARIDE ANTIGEN
MELPHALAN vs MENOTROPINS
MELPHALAN vs MENTHOL