Does METHOTREXATE Cause Aplasia? 199 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 199 reports of Aplasia have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
199
Reports of Aplasia with METHOTREXATE
0.1%
of all METHOTREXATE reports
48
Deaths
121
Hospitalizations
How Dangerous Is Aplasia From METHOTREXATE?
Of the 199 reports, 48 (24.1%) resulted in death, 121 (60.8%) required hospitalization, and 50 (25.1%) were considered life-threatening.
Is Aplasia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 199 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Aplasia?
CYTARABINE (229)
ETOPOSIDE (217)
CYCLOPHOSPHAMIDE (213)
VINCRISTINE (167)
DOXORUBICIN (144)
CARBOPLATIN (136)
DEXAMETHASONE (129)
RITUXIMAB (98)
IFOSFAMIDE (88)
FLUDARABINE (80)
Which METHOTREXATE Alternatives Have Lower Aplasia Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA