Aplasia: Which Medications Cause It? (1,398 Reports Across 179 Drugs)
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Aplasia has been reported as an adverse event with 179 different drugs in the FDA's FAERS database, with 1,398 total reports. 387 of these reports resulted in death.The drugs most commonly associated with Aplasia are CYTARABINE, ETOPOSIDE, and CYCLOPHOSPHAMIDE.
1,398
Total Reports
179
Drugs Involved
387
Deaths
791
Hospitalizations
50.6 yrs
Average Patient Age
48.7% / 51.3%
Female / Male
Which Drugs Cause Aplasia Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| CYTARABINE | 229 | 0.5% | 69 | 129 | 43 |
| ETOPOSIDE | 217 | 0.4% | 32 | 124 | 50 |
| CYCLOPHOSPHAMIDE | 213 | 0.2% | 57 | 147 | 47 |
| METHOTREXATE | 199 | 0.1% | 48 | 121 | 50 |
| VINCRISTINE | 167 | 0.2% | 50 | 108 | 24 |
| DOXORUBICIN | 144 | 0.2% | 61 | 97 | 22 |
| CARBOPLATIN | 136 | 0.2% | 38 | 98 | 26 |
| DEXAMETHASONE | 129 | 0.1% | 37 | 67 | 22 |
| RITUXIMAB | 98 | 0.1% | 39 | 58 | 8 |
| IFOSFAMIDE | 88 | 0.5% | 7 | 49 | 6 |
| FLUDARABINE | 80 | 0.3% | 18 | 36 | 19 |
| PREDNISONE | 80 | 0.1% | 20 | 60 | 24 |
| MELPHALAN | 78 | 0.5% | 13 | 49 | 18 |
| CISPLATIN | 60 | 0.1% | 22 | 33 | 16 |
| PEMETREXED | 60 | 0.3% | 19 | 50 | 6 |
| FLUOROURACIL | 55 | 0.1% | 21 | 28 | 16 |
| PREDNISOLONE | 49 | 0.1% | 17 | 20 | 1 |
| DAUNORUBICIN | 47 | 0.5% | 10 | 22 | 4 |
| VENETOCLAX | 47 | 0.1% | 20 | 10 | 1 |
| IMATINIB | 45 | 0.1% | 6 | 36 | 17 |