Does MESNA Cause Disinhibition? 6 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 6 reports of Disinhibition have been filed in association with MESNA (mesna). This represents 0.1% of all adverse event reports for MESNA.
6
Reports of Disinhibition with MESNA
0.1%
of all MESNA reports
3
Deaths
6
Hospitalizations
How Dangerous Is Disinhibition From MESNA?
Of the 6 reports, 3 (50.0%) resulted in death, 6 (100.0%) required hospitalization, and 1 (16.7%) were considered life-threatening.
Is Disinhibition Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for MESNA. However, 6 reports have been filed with the FAERS database.
What Other Side Effects Does MESNA Cause?
Febrile neutropenia (707)
Pyrexia (352)
Off label use (299)
Cystitis haemorrhagic (294)
Disease progression (273)
Neutropenia (238)
Encephalopathy (226)
Vomiting (200)
Death (184)
Pancytopenia (179)
What Other Drugs Cause Disinhibition?
ARIPIPRAZOLE (233)
OLANZAPINE (215)
QUETIAPINE (194)
CLOZAPINE (171)
AMISULPRIDE (169)
FLUOXETINE (169)
RISPERIDONE (168)
LITHIUM (164)
GABAPENTIN (163)
CITALOPRAM HYDROBROMIDE (157)
Which MESNA Alternatives Have Lower Disinhibition Risk?
MESNA vs METAMIZOLE
MESNA vs METARAMINOL
MESNA vs METAXALONE
MESNA vs METFORMIN
MESNA vs METFORMIN\PIOGLITAZONE