Does MESNA Cause Haematotoxicity? 50 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 50 reports of Haematotoxicity have been filed in association with MESNA (mesna). This represents 1.0% of all adverse event reports for MESNA.
50
Reports of Haematotoxicity with MESNA
1.0%
of all MESNA reports
14
Deaths
3
Hospitalizations
How Dangerous Is Haematotoxicity From MESNA?
Of the 50 reports, 14 (28.0%) resulted in death, 3 (6.0%) required hospitalization, and 4 (8.0%) were considered life-threatening.
Is Haematotoxicity Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for MESNA. However, 50 reports have been filed with the FAERS database.
What Other Side Effects Does MESNA Cause?
Febrile neutropenia (707)
Pyrexia (352)
Off label use (299)
Cystitis haemorrhagic (294)
Disease progression (273)
Neutropenia (238)
Encephalopathy (226)
Vomiting (200)
Death (184)
Pancytopenia (179)
What Other Drugs Cause Haematotoxicity?
CYCLOPHOSPHAMIDE (1,410)
DOXORUBICIN (1,180)
VINCRISTINE (1,038)
RITUXIMAB (812)
CARBOPLATIN (803)
METHOTREXATE (799)
PREDNISONE (730)
CYTARABINE (701)
ETOPOSIDE (677)
CISPLATIN (668)
Which MESNA Alternatives Have Lower Haematotoxicity Risk?
MESNA vs METAMIZOLE
MESNA vs METARAMINOL
MESNA vs METAXALONE
MESNA vs METFORMIN
MESNA vs METFORMIN\PIOGLITAZONE