Does METHOTREXATE Cause Anal fistula? 216 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 216 reports of Anal fistula have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
216
Reports of Anal fistula with METHOTREXATE
0.1%
of all METHOTREXATE reports
1
Deaths
92
Hospitalizations
How Dangerous Is Anal fistula From METHOTREXATE?
Of the 216 reports, 1 (0.5%) resulted in death, 92 (42.6%) required hospitalization, and 4 (1.9%) were considered life-threatening.
Is Anal fistula Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 216 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Anal fistula?
ADALIMUMAB (1,225)
INFLIXIMAB (634)
VEDOLIZUMAB (422)
INFLIXIMAB-DYYB (348)
USTEKINUMAB (160)
BEVACIZUMAB (104)
AZATHIOPRINE (87)
CIPROFLOXACIN (74)
RITUXIMAB (62)
MESALAMINE (55)
Which METHOTREXATE Alternatives Have Lower Anal fistula Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA