Does METHOTREXATE Cause Dementia? 166 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 166 reports of Dementia have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
166
Reports of Dementia with METHOTREXATE
0.1%
of all METHOTREXATE reports
48
Deaths
87
Hospitalizations
How Dangerous Is Dementia From METHOTREXATE?
Of the 166 reports, 48 (28.9%) resulted in death, 87 (52.4%) required hospitalization, and 29 (17.5%) were considered life-threatening.
Is Dementia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 166 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Dementia?
APIXABAN (1,459)
PIMAVANSERIN (1,116)
CARBIDOPA\LEVODOPA (854)
LENALIDOMIDE (651)
SACUBITRIL\VALSARTAN (450)
INSULIN GLARGINE (438)
ADALIMUMAB (401)
INSULIN LISPRO (375)
RIVASTIGMINE (337)
TOFACITINIB (334)
Which METHOTREXATE Alternatives Have Lower Dementia Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA