Does METHOTREXATE Cause Myelopathy? 352 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 352 reports of Myelopathy have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
352
Reports of Myelopathy with METHOTREXATE
0.1%
of all METHOTREXATE reports
52
Deaths
91
Hospitalizations
How Dangerous Is Myelopathy From METHOTREXATE?
Of the 352 reports, 52 (14.8%) resulted in death, 91 (25.9%) required hospitalization, and 14 (4.0%) were considered life-threatening.
Is Myelopathy Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 352 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Myelopathy?
CYTARABINE (185)
BUPRENORPHINE (80)
RITUXIMAB (79)
DEXAMETHASONE (73)
VINCRISTINE (60)
PREDNISOLONE (57)
PREDNISONE (57)
CYCLOPHOSPHAMIDE (51)
NELARABINE (47)
AMPHETAMINE (44)
Which METHOTREXATE Alternatives Have Lower Myelopathy Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA