Does METHOTREXATE Cause Pemphigus? 8,414 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 8,414 reports of Pemphigus have been filed in association with METHOTREXATE (Methotrexate). This represents 3.3% of all adverse event reports for METHOTREXATE.
8,414
Reports of Pemphigus with METHOTREXATE
3.3%
of all METHOTREXATE reports
1,843
Deaths
2,412
Hospitalizations
How Dangerous Is Pemphigus From METHOTREXATE?
Of the 8,414 reports, 1,843 (21.9%) resulted in death, 2,412 (28.7%) required hospitalization, and 2,237 (26.6%) were considered life-threatening.
Is Pemphigus Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 8,414 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Pemphigus?
RITUXIMAB (8,574)
ABATACEPT (8,441)
PREDNISONE (8,260)
LEFLUNOMIDE (8,252)
TOCILIZUMAB (8,210)
FOLIC ACID (8,128)
ADALIMUMAB (8,079)
CETIRIZINE (8,063)
HYDROXYCHLOROQUINE (8,051)
ALENDRONATE (7,947)
Which METHOTREXATE Alternatives Have Lower Pemphigus Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA