Does METHOTREXATE Cause Secondary immunodeficiency? 280 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 280 reports of Secondary immunodeficiency have been filed in association with METHOTREXATE (Methotrexate). This represents 0.1% of all adverse event reports for METHOTREXATE.
280
Reports of Secondary immunodeficiency with METHOTREXATE
0.1%
of all METHOTREXATE reports
218
Deaths
28
Hospitalizations
How Dangerous Is Secondary immunodeficiency From METHOTREXATE?
Of the 280 reports, 218 (77.9%) resulted in death, 28 (10.0%) required hospitalization, and 2 (0.7%) were considered life-threatening.
Is Secondary immunodeficiency Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for METHOTREXATE. However, 280 reports have been filed with the FAERS database.
What Other Side Effects Does METHOTREXATE Cause?
Drug ineffective (70,142)
Rheumatoid arthritis (29,254)
Off label use (24,020)
Pain (23,773)
Drug intolerance (22,555)
Arthralgia (21,831)
Fatigue (19,885)
Nausea (18,715)
Joint swelling (17,657)
Drug hypersensitivity (16,677)
What Other Drugs Cause Secondary immunodeficiency?
PREDNISONE (402)
CYCLOPHOSPHAMIDE (362)
VINCRISTINE (331)
DEXAMETHASONE (282)
METHYLPREDNISOLONE (255)
CYTARABINE (250)
MERCAPTOPURINE (241)
DAUNORUBICIN (240)
ETOPOSIDE (240)
ASPARAGINASE (233)
Which METHOTREXATE Alternatives Have Lower Secondary immunodeficiency Risk?
METHOTREXATE vs METHOXSALEN
METHOTREXATE vs METHOXY POLYETHYLENE GLYCOL-EPOETIN BETA
METHOTREXATE vs METHYL ALCOHOL
METHOTREXATE vs METHYLCOBALAMIN
METHOTREXATE vs METHYLDOPA