Does PEGASPARGASE Cause Pancytopenia? 260 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 260 reports of Pancytopenia have been filed in association with PEGASPARGASE (ONCASPAR). This represents 2.3% of all adverse event reports for PEGASPARGASE.
260
Reports of Pancytopenia with PEGASPARGASE
2.3%
of all PEGASPARGASE reports
50
Deaths
219
Hospitalizations
How Dangerous Is Pancytopenia From PEGASPARGASE?
Of the 260 reports, 50 (19.2%) resulted in death, 219 (84.2%) required hospitalization, and 30 (11.5%) were considered life-threatening.
Is Pancytopenia Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PEGASPARGASE. However, 260 reports have been filed with the FAERS database.
What Other Side Effects Does PEGASPARGASE Cause?
Febrile neutropenia (1,589)
Pyrexia (706)
Febrile bone marrow aplasia (668)
Sepsis (548)
Vomiting (530)
Neutropenia (521)
Abdominal pain (469)
Hypertriglyceridaemia (399)
Hypotension (388)
Thrombocytopenia (382)
What Other Drugs Cause Pancytopenia?
METHOTREXATE (5,377)
CYCLOPHOSPHAMIDE (3,351)
CARBOPLATIN (2,910)
RITUXIMAB (2,400)
LENALIDOMIDE (2,259)
DOXORUBICIN (2,212)
VINCRISTINE (2,180)
ETOPOSIDE (2,129)
DEXAMETHASONE (2,053)
PREDNISONE (1,743)
Which PEGASPARGASE Alternatives Have Lower Pancytopenia Risk?
PEGASPARGASE vs PEGASYS
PEGASPARGASE vs PEGCETACOPLAN
PEGASPARGASE vs PEGFILGRASTIM
PEGASPARGASE vs PEGFILGRASTIM-APGF
PEGASPARGASE vs PEGFILGRASTIM-BMEZ