Does PEMBROLIZUMAB Cause Agranulocytosis? 196 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 196 reports of Agranulocytosis have been filed in association with PEMBROLIZUMAB (KEYTRUDA). This represents 0.2% of all adverse event reports for PEMBROLIZUMAB.
196
Reports of Agranulocytosis with PEMBROLIZUMAB
0.2%
of all PEMBROLIZUMAB reports
25
Deaths
144
Hospitalizations
How Dangerous Is Agranulocytosis From PEMBROLIZUMAB?
Of the 196 reports, 25 (12.8%) resulted in death, 144 (73.5%) required hospitalization, and 58 (29.6%) were considered life-threatening.
Is Agranulocytosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PEMBROLIZUMAB. However, 196 reports have been filed with the FAERS database.
What Other Side Effects Does PEMBROLIZUMAB Cause?
Malignant neoplasm progression (10,111)
Death (4,744)
Diarrhoea (4,251)
Fatigue (3,833)
Off label use (3,416)
Product use in unapproved indication (3,191)
Pyrexia (3,155)
Rash (2,900)
Nausea (2,670)
Decreased appetite (2,486)
What Other Drugs Cause Agranulocytosis?
CLOZAPINE (1,766)
CYCLOPHOSPHAMIDE (1,242)
RITUXIMAB (1,154)
SULFAMETHOXAZOLE\TRIMETHOPRIM (797)
PANTOPRAZOLE (599)
METHOTREXATE (550)
SODIUM (549)
EPIRUBICIN (491)
METAMIZOLE (438)
DOCETAXEL (436)
Which PEMBROLIZUMAB Alternatives Have Lower Agranulocytosis Risk?
PEMBROLIZUMAB vs PEMETREXED
PEMBROLIZUMAB vs PEMIGATINIB
PEMBROLIZUMAB vs PENICILLAMINE
PEMBROLIZUMAB vs PENICILLIN
PEMBROLIZUMAB vs PENICILLIN G