Does PYRAZINAMIDE Cause Hepatic failure? 77 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 77 reports of Hepatic failure have been filed in association with PYRAZINAMIDE (Pyrazinamide). This represents 1.4% of all adverse event reports for PYRAZINAMIDE.
77
Reports of Hepatic failure with PYRAZINAMIDE
1.4%
of all PYRAZINAMIDE reports
51
Deaths
26
Hospitalizations
How Dangerous Is Hepatic failure From PYRAZINAMIDE?
Of the 77 reports, 51 (66.2%) resulted in death, 26 (33.8%) required hospitalization, and 2 (2.6%) were considered life-threatening.
Is Hepatic failure Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PYRAZINAMIDE. However, 77 reports have been filed with the FAERS database.
What Other Side Effects Does PYRAZINAMIDE Cause?
Drug-induced liver injury (588)
Drug reaction with eosinophilia and systemic symptoms (492)
Paradoxical drug reaction (407)
Vomiting (307)
Pyrexia (301)
Drug ineffective (298)
Off label use (288)
Hepatotoxicity (279)
Drug resistance (269)
Nausea (251)
What Other Drugs Cause Hepatic failure?
ACETAMINOPHEN (1,392)
RIBAVIRIN (888)
CYCLOPHOSPHAMIDE (629)
METHOTREXATE (598)
BEVACIZUMAB (558)
SOFOSBUVIR (525)
RITUXIMAB (513)
VINCRISTINE (468)
DOXORUBICIN (462)
PREDNISOLONE (425)
Which PYRAZINAMIDE Alternatives Have Lower Hepatic failure Risk?
PYRAZINAMIDE vs PYRIDOSTIGMINE
PYRAZINAMIDE vs PYRIDOXINE
PYRAZINAMIDE vs PYRIDOXINE\THIAMINE
PYRAZINAMIDE vs PYRIMETHAMINE
PYRAZINAMIDE vs PYROTINIB