Does PYRAZINAMIDE Cause Hepatic necrosis? 14 Reports in FDA Database
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According to the FDA Adverse Event Reporting System (FAERS), 14 reports of Hepatic necrosis have been filed in association with PYRAZINAMIDE (Pyrazinamide). This represents 0.3% of all adverse event reports for PYRAZINAMIDE.
14
Reports of Hepatic necrosis with PYRAZINAMIDE
0.3%
of all PYRAZINAMIDE reports
2
Deaths
13
Hospitalizations
How Dangerous Is Hepatic necrosis From PYRAZINAMIDE?
Of the 14 reports, 2 (14.3%) resulted in death, 13 (92.9%) required hospitalization, and 9 (64.3%) were considered life-threatening.
Is Hepatic necrosis Listed in the Official Label?
This adverse event is not currently listed in the official FDA drug label for PYRAZINAMIDE. However, 14 reports have been filed with the FAERS database.
What Other Side Effects Does PYRAZINAMIDE Cause?
Drug-induced liver injury (588)
Drug reaction with eosinophilia and systemic symptoms (492)
Paradoxical drug reaction (407)
Vomiting (307)
Pyrexia (301)
Drug ineffective (298)
Off label use (288)
Hepatotoxicity (279)
Drug resistance (269)
Nausea (251)
What Other Drugs Cause Hepatic necrosis?
ACETAMINOPHEN (216)
CYCLOPHOSPHAMIDE (83)
PREDNISONE (78)
VENLAFAXINE (69)
TACROLIMUS (67)
MYCOPHENOLATE MOFETIL (61)
METHOTREXATE (55)
METHYLPREDNISOLONE (55)
SOMATROPIN (50)
DIMETHYL SULFONE (49)
Which PYRAZINAMIDE Alternatives Have Lower Hepatic necrosis Risk?
PYRAZINAMIDE vs PYRIDOSTIGMINE
PYRAZINAMIDE vs PYRIDOXINE
PYRAZINAMIDE vs PYRIDOXINE\THIAMINE
PYRAZINAMIDE vs PYRIMETHAMINE
PYRAZINAMIDE vs PYROTINIB