Anal fissure: Which Medications Cause It? (4,094 Reports Across 171 Drugs)
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Anal fissure has been reported as an adverse event with 171 different drugs in the FDA's FAERS database, with 4,094 total reports. 68 of these reports resulted in death.The drugs most commonly associated with Anal fissure are INFLIXIMAB-DYYB, INFLIXIMAB, and ADALIMUMAB.
4,094
Total Reports
171
Drugs Involved
68
Deaths
1,320
Hospitalizations
45.4 yrs
Average Patient Age
57.1% / 42.9%
Female / Male
Which Drugs Cause Anal fissure Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| INFLIXIMAB-DYYB | 995 | 3.9% | 10 | 286 | 4 |
| INFLIXIMAB | 752 | 0.5% | 5 | 167 | 9 |
| ADALIMUMAB | 415 | 0.1% | 1 | 147 | 6 |
| VEDOLIZUMAB | 377 | 0.5% | 1 | 119 | 1 |
| METHOTREXATE | 156 | 0.1% | 0 | 56 | 0 |
| AZATHIOPRINE | 58 | 0.2% | 0 | 7 | 0 |
| ISOTRETINOIN | 57 | 0.2% | 0 | 14 | 0 |
| PREDNISONE | 53 | 0.0% | 0 | 14 | 0 |
| RITUXIMAB | 52 | 0.0% | 1 | 13 | 1 |
| ADALIMUMAB-ADAZ | 48 | 0.7% | 2 | 4 | 0 |
| METRONIDAZOLE | 47 | 0.2% | 0 | 22 | 0 |
| FLUOROURACIL | 43 | 0.1% | 9 | 29 | 0 |
| CIPROFLOXACIN | 42 | 0.1% | 0 | 4 | 0 |
| ADALIMUMAB-AFZB | 41 | 2.0% | 0 | 10 | 0 |
| USTEKINUMAB | 40 | 0.1% | 0 | 12 | 0 |
| BEVACIZUMAB | 39 | 0.1% | 13 | 29 | 0 |
| ETANERCEPT | 37 | 0.0% | 0 | 3 | 0 |
| LEFLUNOMIDE | 37 | 0.1% | 0 | 5 | 0 |
| SULFASALAZINE | 36 | 0.1% | 0 | 0 | 0 |
| TOFACITINIB | 35 | 0.0% | 0 | 6 | 0 |