Anion gap: Which Medications Cause It? (606 Reports Across 62 Drugs)
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Anion gap has been reported as an adverse event with 62 different drugs in the FDA's FAERS database, with 606 total reports. 550 of these reports resulted in death.The drugs most commonly associated with Anion gap are ACETAMINOPHEN, METFORMIN, and FENTANYL.
606
Total Reports
62
Drugs Involved
550
Deaths
170
Hospitalizations
44.0 yrs
Average Patient Age
59.3% / 40.7%
Female / Male
Which Drugs Cause Anion gap Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ACETAMINOPHEN | 238 | 0.2% | 235 | 55 | 10 |
| METFORMIN | 96 | 0.1% | 79 | 31 | 8 |
| FENTANYL | 44 | 0.1% | 44 | 13 | 0 |
| IBUPROFEN | 39 | 0.0% | 38 | 12 | 4 |
| NOREPINEPHRINE | 28 | 0.6% | 28 | 9 | 0 |
| DIPHENHYDRAMINE | 27 | 0.1% | 26 | 7 | 2 |
| ALPRAZOLAM | 26 | 0.1% | 26 | 8 | 2 |
| AMLODIPINE | 25 | 0.0% | 24 | 7 | 2 |
| SODIUM BICARBONATE | 25 | 0.8% | 24 | 8 | 1 |
| GABAPENTIN | 23 | 0.0% | 22 | 7 | 2 |
| LORAZEPAM | 20 | 0.1% | 19 | 4 | 1 |
| EPINEPHRINE | 18 | 0.1% | 18 | 5 | 0 |
| QUETIAPINE | 18 | 0.0% | 17 | 5 | 0 |
| ACETAMINOPHEN\HYDROCODONE | 17 | 0.0% | 14 | 8 | 0 |
| EMPAGLIFLOZIN | 17 | 0.1% | 7 | 7 | 1 |
| OXYCODONE | 17 | 0.0% | 15 | 5 | 3 |
| VASOPRESSIN | 17 | 0.9% | 17 | 8 | 0 |
| ACETAMINOPHEN\BUTALBITAL\CAFFEINE | 16 | 1.4% | 16 | 0 | 0 |
| ALCOHOL | 16 | 0.1% | 14 | 1 | 1 |
| CYCLOBENZAPRINE | 16 | 0.2% | 16 | 2 | 0 |