Anticholinergic syndrome: Which Medications Cause It? (1,229 Reports Across 135 Drugs)
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Anticholinergic syndrome has been reported as an adverse event with 135 different drugs in the FDA's FAERS database, with 1,229 total reports. 51 of these reports resulted in death.The drugs most commonly associated with Anticholinergic syndrome are QUETIAPINE, DIPHENHYDRAMINE, and OLANZAPINE.
1,229
Total Reports
135
Drugs Involved
51
Deaths
735
Hospitalizations
39.7 yrs
Average Patient Age
59.2% / 40.8%
Female / Male
Which Drugs Cause Anticholinergic syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| QUETIAPINE | 250 | 0.3% | 0 | 160 | 64 |
| DIPHENHYDRAMINE | 168 | 0.7% | 16 | 139 | 25 |
| OLANZAPINE | 164 | 0.3% | 6 | 84 | 9 |
| AMITRIPTYLINE | 146 | 0.7% | 21 | 61 | 29 |
| RISPERIDONE | 138 | 0.2% | 0 | 54 | 9 |
| MIRTAZAPINE | 94 | 0.3% | 0 | 22 | 14 |
| ALPRAZOLAM | 68 | 0.1% | 0 | 58 | 19 |
| OXYBUTYNIN | 66 | 0.9% | 0 | 14 | 0 |
| TRAZODONE | 63 | 0.3% | 0 | 16 | 3 |
| VENLAFAXINE | 63 | 0.1% | 0 | 43 | 12 |
| HYDROXYZINE | 59 | 0.5% | 0 | 44 | 5 |
| ATROPINE | 57 | 2.0% | 0 | 43 | 5 |
| ACETAMINOPHEN | 56 | 0.0% | 20 | 45 | 9 |
| PAROXETINE | 55 | 0.3% | 0 | 23 | 7 |
| HALOPERIDOL | 54 | 0.3% | 0 | 15 | 1 |
| TOLTERODINE | 54 | 2.2% | 0 | 8 | 0 |
| CARBIDOPA\LEVODOPA | 52 | 0.1% | 0 | 0 | 0 |
| LOPERAMIDE | 52 | 0.3% | 0 | 1 | 0 |
| RANITIDINE | 52 | 0.0% | 0 | 7 | 0 |
| LORAZEPAM | 50 | 0.2% | 2 | 34 | 27 |