Application site discolouration: Which Medications Cause It? (2,951 Reports Across 83 Drugs)
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Application site discolouration has been reported as an adverse event with 83 different drugs in the FDA's FAERS database, with 2,951 total reports. 4 of these reports resulted in death.The drugs most commonly associated with Application site discolouration are SUMATRIPTAN, BUPRENORPHINE, and INGENOL MEBUTATE.
2,951
Total Reports
83
Drugs Involved
4
Deaths
88
Hospitalizations
49.6 yrs
Average Patient Age
77.5% / 22.5%
Female / Male
Which Drugs Cause Application site discolouration Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| SUMATRIPTAN | 684 | 3.9% | 0 | 2 | 0 |
| BUPRENORPHINE | 208 | 0.3% | 0 | 1 | 0 |
| INGENOL MEBUTATE | 115 | 3.8% | 0 | 0 | 0 |
| MECHLORETHAMINE | 101 | 3.9% | 1 | 2 | 0 |
| ESTRADIOL | 89 | 0.3% | 0 | 0 | 0 |
| NICOTINE | 87 | 0.3% | 0 | 1 | 0 |
| MINOXIDIL | 76 | 0.1% | 0 | 1 | 0 |
| SALICYLIC ACID | 76 | 3.5% | 0 | 1 | 0 |
| BECAPLERMIN | 74 | 3.6% | 0 | 8 | 0 |
| DICLOFENAC | 67 | 0.1% | 0 | 4 | 0 |
| METHYLPHENIDATE | 61 | 0.2% | 0 | 0 | 0 |
| PEGFILGRASTIM | 61 | 0.1% | 0 | 0 | 0 |
| ESTRADIOL\NORETHINDRONE | 54 | 1.3% | 0 | 0 | 0 |
| HYDROGEN PEROXIDE | 51 | 11.8% | 0 | 1 | 0 |
| FENTANYL | 42 | 0.0% | 0 | 0 | 1 |
| ETHINYL ESTRADIOL\NORELGESTROMIN | 41 | 0.6% | 0 | 0 | 0 |
| OXYTROL FOR WOMEN | 41 | 1.4% | 0 | 0 | 0 |
| DOCOSANOL | 38 | 0.5% | 0 | 0 | 0 |
| RIVASTIGMINE | 37 | 0.4% | 1 | 5 | 0 |
| CRISABOROLE | 32 | 0.4% | 0 | 0 | 0 |