Capillary leak syndrome: Which Medications Cause It? (1,399 Reports Across 128 Drugs)
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Capillary leak syndrome has been reported as an adverse event with 128 different drugs in the FDA's FAERS database, with 1,399 total reports. 335 of these reports resulted in death.The drugs most commonly associated with Capillary leak syndrome are GEMCITABINE, TAGRAXOFUSP-ERZS, and PACLITAXEL.
1,399
Total Reports
128
Drugs Involved
335
Deaths
785
Hospitalizations
48.9 yrs
Average Patient Age
51.9% / 48.1%
Female / Male
Which Drugs Cause Capillary leak syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| GEMCITABINE | 134 | 0.4% | 56 | 56 | 20 |
| TAGRAXOFUSP-ERZS | 110 | 25.1% | 35 | 55 | 13 |
| PACLITAXEL | 97 | 0.1% | 17 | 34 | 12 |
| CYCLOPHOSPHAMIDE | 86 | 0.1% | 26 | 59 | 24 |
| DOCETAXEL | 81 | 0.1% | 3 | 41 | 14 |
| CYTARABINE | 68 | 0.2% | 21 | 47 | 10 |
| METHOTREXATE | 65 | 0.0% | 20 | 41 | 6 |
| NIVOLUMAB | 61 | 0.1% | 15 | 43 | 9 |
| RITUXIMAB | 58 | 0.0% | 14 | 24 | 12 |
| FILGRASTIM | 52 | 0.4% | 11 | 34 | 13 |
| FLUDARABINE | 52 | 0.2% | 20 | 25 | 13 |
| CYCLOSPORINE | 46 | 0.1% | 16 | 20 | 3 |
| VINCRISTINE | 43 | 0.1% | 7 | 39 | 13 |
| AMLODIPINE | 40 | 0.1% | 7 | 39 | 26 |
| PEMBROLIZUMAB | 39 | 0.1% | 5 | 22 | 7 |
| CLOFARABINE | 36 | 2.5% | 17 | 22 | 3 |
| CARBOPLATIN | 35 | 0.0% | 11 | 16 | 2 |
| GEMCITABINE\GEMCITABINE | 34 | 0.3% | 6 | 14 | 6 |
| PEGFILGRASTIM | 34 | 0.0% | 8 | 16 | 6 |
| DINUTUXIMAB | 33 | 4.9% | 6 | 19 | 7 |