Compartment syndrome: Which Medications Cause It? (1,809 Reports Across 196 Drugs)
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Compartment syndrome has been reported as an adverse event with 196 different drugs in the FDA's FAERS database, with 1,809 total reports. 156 of these reports resulted in death.The drugs most commonly associated with Compartment syndrome are ASPIRIN, RIVAROXABAN, and OXYCODONE.
1,809
Total Reports
196
Drugs Involved
156
Deaths
1,315
Hospitalizations
46.9 yrs
Average Patient Age
46.9% / 53.1%
Female / Male
Which Drugs Cause Compartment syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| ASPIRIN | 99 | 0.1% | 6 | 68 | 12 |
| RIVAROXABAN | 97 | 0.1% | 6 | 85 | 10 |
| OXYCODONE | 93 | 0.1% | 13 | 73 | 10 |
| HEPARIN | 83 | 0.5% | 3 | 58 | 19 |
| WARFARIN | 77 | 0.2% | 1 | 56 | 4 |
| ENOXAPARIN | 71 | 0.3% | 5 | 49 | 6 |
| DIPHENHYDRAMINE | 67 | 0.3% | 0 | 64 | 28 |
| QUETIAPINE | 65 | 0.1% | 1 | 49 | 11 |
| AMLODIPINE | 57 | 0.1% | 9 | 53 | 37 |
| ATORVASTATIN | 52 | 0.1% | 0 | 45 | 8 |
| BUPRENORPHINE | 51 | 0.1% | 9 | 49 | 0 |
| LORAZEPAM | 49 | 0.2% | 7 | 42 | 4 |
| CLOPIDOGREL BISULFATE | 47 | 0.1% | 10 | 35 | 3 |
| OLANZAPINE | 44 | 0.1% | 0 | 37 | 4 |
| APIXABAN | 41 | 0.0% | 3 | 30 | 10 |
| FENTANYL | 41 | 0.0% | 3 | 34 | 10 |
| NOREPINEPHRINE | 40 | 0.8% | 0 | 24 | 26 |
| VILDAGLIPTIN | 40 | 1.9% | 0 | 38 | 20 |
| CLONAZEPAM | 39 | 0.1% | 10 | 35 | 0 |
| EPINEPHRINE | 38 | 0.3% | 1 | 25 | 24 |