Cytokine release syndrome: Which Medications Cause It? (15,608 Reports Across 240 Drugs)
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Cytokine release syndrome has been reported as an adverse event with 240 different drugs in the FDA's FAERS database, with 15,608 total reports. 2,914 of these reports resulted in death.The drugs most commonly associated with Cytokine release syndrome are AXICABTAGENE CILOLEUCEL, CYCLOPHOSPHAMIDE, and TISAGENLECLEUCEL.
15,608
Total Reports
240
Drugs Involved
2,914
Deaths
7,381
Hospitalizations
57.1 yrs
Average Patient Age
40.9% / 59.1%
Female / Male
Which Drugs Cause Cytokine release syndrome Most Often?
| Drug | Reports | % of Drug Reports | Deaths | Hosp. | Life-Threat. |
|---|---|---|---|---|---|
| AXICABTAGENE CILOLEUCEL | 4,140 | 48.2% | 718 | 1,880 | 397 |
| CYCLOPHOSPHAMIDE | 2,263 | 1.8% | 387 | 1,449 | 252 |
| TISAGENLECLEUCEL | 1,660 | 39.3% | 505 | 696 | 277 |
| FLUDARABINE | 1,458 | 6.2% | 238 | 940 | 203 |
| RITUXIMAB | 1,404 | 0.8% | 234 | 846 | 117 |
| BLINATUMOMAB | 952 | 10.4% | 225 | 304 | 126 |
| DEXAMETHASONE | 853 | 0.7% | 155 | 447 | 107 |
| DOXORUBICIN | 850 | 1.0% | 156 | 543 | 64 |
| BREXUCABTAGENE AUTOLEUCEL | 827 | 47.3% | 168 | 436 | 97 |
| VINCRISTINE | 771 | 1.1% | 147 | 475 | 58 |
| PREDNISONE | 706 | 0.5% | 111 | 500 | 42 |
| IDECABTAGENE VICLEUCEL | 607 | 58.5% | 57 | 253 | 43 |
| CILTACABTAGENE AUTOLEUCEL | 570 | 15.0% | 115 | 340 | 35 |
| EPCORITAMAB | 551 | 27.0% | 66 | 507 | 56 |
| NIVOLUMAB | 551 | 0.6% | 115 | 328 | 117 |
| OXALIPLATIN | 474 | 0.8% | 50 | 209 | 46 |
| LENALIDOMIDE | 442 | 0.1% | 48 | 340 | 30 |
| CYTARABINE | 439 | 1.0% | 81 | 194 | 62 |
| GLOFITAMAB | 415 | 37.2% | 102 | 239 | 17 |
| TECLISTAMAB-CQYV | 406 | 25.5% | 47 | 131 | 12 |