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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Depressed mood: Which Medications Cause It? (39,453 Reports Across 987 Drugs)

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Depressed mood has been reported as an adverse event with 987 different drugs in the FDA's FAERS database, with 39,453 total reports. 964 of these reports resulted in death.The drugs most commonly associated with Depressed mood are ADALIMUMAB, TOFACITINIB, and DULOXETINE.

39,453
Total Reports
987
Drugs Involved
964
Deaths
8,080
Hospitalizations
50.3 yrs
Average Patient Age
67.3% / 32.7%
Female / Male

Which Drugs Cause Depressed mood Most Often?

Drug Reports % of Drug Reports Deaths Hosp. Life-Threat.
ADALIMUMAB 1,351 0.3% 36 443 32
TOFACITINIB 1,329 0.9% 8 99 5
DULOXETINE 1,187 2.3% 4 113 36
LEVONORGESTREL 841 0.7% 2 273 26
FINGOLIMOD 746 1.1% 4 85 17
MONTELUKAST 737 2.7% 4 116 33
LEVOTHYROXINE 671 1.1% 1 105 6
ETANERCEPT 665 0.2% 9 96 18
PREGABALIN 645 0.6% 23 141 59
TERIFLUNOMIDE 627 1.6% 1 84 3
ARIPIPRAZOLE 625 0.9% 14 253 29
VENLAFAXINE 596 1.2% 10 215 43
QUETIAPINE 583 0.8% 15 276 49
CARBIDOPA\LEVODOPA 582 1.0% 35 282 14
SERTRALINE 570 1.0% 3 174 61
ISOTRETINOIN 506 1.5% 6 12 6
DUPILUMAB 503 0.1% 0 37 2
FLUOXETINE 446 1.4% 16 126 57
SECUKINUMAB 418 0.3% 18 88 42
SACUBITRIL\VALSARTAN 406 0.4% 14 77 13

View all 987 drugs →

Top 3 Drugs Associated With Depressed mood

1,351 reports
1,329 reports
1,187 reports

Related Side Effects

Drug ineffective (1,049,718) Off label use (762,782) Death (660,423) Fatigue (599,248) Nausea (562,301) Diarrhoea (491,550) Pain (471,975) Headache (460,069) Dyspnoea (409,496) Dizziness (352,922)