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Important: This site presents data from the FDA Adverse Event Reporting System (FAERS). A report does not mean the drug caused the event. Full disclaimer.

Drug effect less than expected: Which Medications Cause It? (11,208 Reports Across 394 Drugs)

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Drug effect less than expected has been reported as an adverse event with 394 different drugs in the FDA's FAERS database, with 11,208 total reports. 88 of these reports resulted in death.The drugs most commonly associated with Drug effect less than expected are DUPILUMAB, DICLOFENAC, and VEDOLIZUMAB.

11,208
Total Reports
394
Drugs Involved
88
Deaths
802
Hospitalizations
51.3 yrs
Average Patient Age
60.6% / 39.4%
Female / Male

Which Drugs Cause Drug effect less than expected Most Often?

Drug Reports % of Drug Reports Deaths Hosp. Life-Threat.
DUPILUMAB 1,204 0.3% 0 25 0
DICLOFENAC 647 0.8% 0 2 0
VEDOLIZUMAB 461 0.6% 1 103 1
PRABOTULINUMTOXINA-XVFS 354 10.9% 0 0 0
OFATUMUMAB 319 1.1% 1 14 4
EPTINEZUMAB-JJMR 298 4.2% 0 8 0
IBUPROFEN 218 0.3% 0 3 0
TOFACITINIB 210 0.1% 0 13 1
SECUKINUMAB 190 0.1% 1 8 1
ACETAMINOPHEN\IBUPROFEN 163 5.4% 0 0 0
ACETAMINOPHEN\ASPIRIN\CAFFEINE 134 1.2% 0 0 0
APREMILAST 133 0.1% 2 4 0
AMPHETAMINE ASPARTATE\AMPHETAMINE\DEXTROAMPHETAMINE SACCHARATE\DEXTROAMPHETAMINE 130 0.8% 0 1 0
VIBEGRON 125 2.7% 0 1 0
LISDEXAMFETAMINE DIMESYLATE 121 0.7% 0 4 0
MEPOLIZUMAB 119 0.3% 2 74 2
CALCIUM OXYBATE\MAGNESIUM OXYBATE\POTASSIUM OXYBATE\SODIUM OXYBATE 110 1.5% 0 28 0
CARBIDOPA\LEVODOPA 107 0.2% 0 8 0
LEVODOPA 99 1.5% 2 2 0
METHYLPHENIDATE 94 0.3% 0 2 1

View all 394 drugs →

Top 3 Drugs Associated With Drug effect less than expected

1,204 reports
647 reports
461 reports

Related Side Effects

Drug ineffective (1,049,718) Off label use (762,782) Death (660,423) Fatigue (599,248) Nausea (562,301) Diarrhoea (491,550) Pain (471,975) Headache (460,069) Dyspnoea (409,496) Dizziness (352,922)